ABSTRACT
Botulinum neurotoxin is widely used to treat a variety of movement disorders, especially dystonia and spasticity. There botúlica different preparations of botulinum type A, that because biologics are difficult to compare. AbobotulinumtoxinA (Dysport ®) has recently been introduced in Chile for treating dystonia and spasticity. The aim of this paper is to provide a review by experts on the existing evidence and propose a practical guide to the use of the drug. Methods and Results: A group of Chilean experts met on 6 and 7 July 2012 to review AbobotulinumtoxinA doses along with injection protocols for dystonia, spasticity and other movement disorders. We worked in two groups, one composed of neurologists who reviewed the on dystonias and other by physiatrists who reviewed the indications for spasticity. Conclusions: Finally, there is a proposal in terms of dose, injection points and recommendations for dystonia and spasticity...
La neurotoxina botulínica es ampliamente usada para tratar una variedad de trastornos del movimiento, especialmente la distonía y la espasticidad. Existen diferentes preparados de toxina botúlica tipo A, que por ser productos biológicos resultan difícilmente comparables. La abobotulinumtoxinA (Dysport®) ha sido introducida en Chile recientemente para el tratamiento de la distonía y la espasticidad. El objetivo de este trabajo es entregar una revisión hecha por expertos sobre la evidencia existente y plantear una guía práctica para el uso del medicamento. Métodos y Resultados: Un grupo de expertos chilenos se reunieron el 6 y 7 julio de 2012 para revisar las dosis abobotulinumtoxin A, junto con los protocolos de inyección para la distonía, la espasticidad y otros trastornos del movimiento. Se trabajó en dos grupos, uno compuesto por neurólogos que revisaron las indicaciones en distonías y otro por fisiatras que revisaron las indicaciones para espasticidad. Conclusiones: Finalmente, se realiza una propuesta en cuanto a dosis, puntos a inyectar y recomendaciones para la distonia y espasticidad...
Subject(s)
Humans , Dystonia/drug therapy , Muscle Spasticity/drug therapy , Neuromuscular Agents/administration & dosage , Botulinum Toxins, Type A/administration & dosage , Chile , Consensus , Evidence-Based Medicine , Neuromuscular Agents/adverse effects , Practice Guidelines as Topic , Botulinum Toxins, Type A/adverse effectsABSTRACT
Introduction: Aging involves the loss of functional reserve with alteration of multiple systems. This influences the deterioration of various aspects of health and quality of life. To improve these aspects there are different types of interventions in which physical activity has a prominent role. Objective: To evaluate the effectiveness of one type of physical activity in improving the quality of life of an elderly population of the community. Subjects and methods: We recruited 71 subjects aged 60 years attending a club of elderly. Were randomized into 2 groups (intervention and control) by a blinded observer. The intervention was aerobic physical activity for 30 minutes and calisthenics exercises for heating and cooling, for 10 weeks and 3 times a week. We evaluated 8 dimensions of quality of life at the beginning and end of the intervention by the SF-36. Results: Both groups had similar values at baseline. The intervention group improved clinically (5 to 25 points) and statistically significant (p <0.05) in the 8 dimensions of quality of life. The control group showed a modest improvement in 3 items exploring psychosocial aspects of quality of life. Conclusion: The physical activity in the community is a therapeutic alternative economic, easy to implement, safe to apply and produces a great impact on improving the quality of life of the population over 60 years.
Subject(s)
Humans , Male , Female , Aged , Aged , Exercise , Exercise Movement Techniques , Quality of LifeABSTRACT
La Hipertensión arterial (HTA) es una de las patologías prevalentes en nuestra población adulta mayor y un problema de salud pública, siendo el ejercicio de tipo aeróbico el que ha mostrado los resultados más beneficiosos como herramienta terapéutica. El objetivo de este estudio es evaluar el impacto de un programa de ejercicios aeróbico submáximo sobre las cifras tensionales, en una muestra de adultos mayores hipertensos. Método: ensayo clínico randomizado controlado simple ciego. Ingresan 39 voluntarios quedando 18 pacientes en el grupo intervenido (GE) y 19 pacientes en el grupo control (GC). El GE ingresa a un protocolo de ejercicios aeróbicos de 10 semanas. El GC continúa con un programa habitual. Se efectuaron mediciones de presión arterial (PA) al comienzo y al final del programa en ambos grupos. Resultados: en el análisis pre y post test de las cifras de PA de cada grupo por separado, sólo el GE obtuvo una diferencia estadísticamente significativa (p<0.05). El análisis comparado de ambos grupos no arroja resultados estadísticamente significativos. Sin embargo, el análisis de los intervalos de confianza obtiene una diferencia estadísticamente significativa entre ambos grupos. Conclusiones: Los resultados de este estudio reforzarían el hecho de que el ejercicio es una herramienta coadyuvante efectiva y segura en el tratamiento de la HTA en adultos mayores.
The arterial Hypertension (HTA) is a one of the prevalentes pathologies in our greater adult population and a problem of public health, being the exercise of aerobico type the one that has shown the most beneficial results like therapeutic tool. The objective of this study is to evaluate the impact of a submaximum program of exercises aeróbico on the tensional numbers, in a sample of hypertense greater adults. Method: randomizado clinical test controlled simple blind person. 18 patients in the taken part group (GE) and 19 patients in the group enter 39 volunteers being control (GC). GE enters to a protocol of aerobicos exercises of 10 weeks. The GC continues with a habitual program. Measurements of arterial pressure took place in the beginning (PA) and at the end of the program in both groups. Results: in the analysis pre and post test of the numbers of PA of each group separately, only the GE obtained one differentiates statistically significant (p<05). The analysis comparative ng of both groups does not throw statistically significant results. Nevertheless, the analysis of the confidence intervals obtains a statistically significant difference between both groups. Conclusions: The results of this study would reinforce the fact that the exercise is an effective and safe helping tool in the treatment of the HTA in greater adults.